UKB Somatic Browser

Find mutations and their links to proteins and diseases

Explore clonal hematopoiesis associations with proteins and disease in UK Biobank.

Search by mutated gene (e.g. DNMT3A) or protein (e.g. BCL2).

Type a gene (e.g. DNMT3A) or protein (e.g. TCL1A), then press Enter or choose a dataset below.

Variant Analysis

Single-variant level details, including VAFs and unadjusted age association

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Filter by Type of CH

Minimum Frequency

PACER Results

Passenger approximated clonal expansion rate (PACER). Higher posterior mean estimates indicate greater abundance of age-adjusted passenger mutations, suggesting greater fitness (see Weinstock et al., 2023 for details).

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PACER quantifies age-adjusted passenger mutation abundance relative to DNMT3A-R882.

PheWAS Results

Explore mutation-phenotype associations, adjusted for age, smoking, and genetic ancestry.

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Filter by Phenotype Group

Maximum LFSR

PWAS Results

Explore mutation-protein associations, adjusted for age, smoking, cell type composition, and genetic ancestry.

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Filter by Protein

Filter by Mutation Type

Maximum LFSR

Show significant only (LFSR < 0.05)

About the Weinstock Lab

Trying to understand how DNA changes in our blood cells as we age.

The UKB Somatic Variation Browser is developed by the Weinstock Lab at Emory University's Department of Human Genetics.

Accompanying manuscript

Affiliations

We are members of the Winship Cancer Institute and the Center of Computational and Quantitative Genetics .